The moisture content of MCC influences compaction properties, tensile strength, and Viscoelastic properties. Moisture within the pores of MCC may act as an internal lubricant
Particle size has a very little effect on the tabletability of neat MCC, i.e., not lubricated nor Blended with other excipients or active pharmaceutical ingredients (APIs).
The MCC morphology, described by the length of particles Length (L) and their Width (D), was one of the most important factors influencing tabletability.
Modifying the hydrolysis conditions, including temperature, time, and acid concentration, Also has a very little impact on the degree of crystallinity, i.e., the regularity of the Arrangement
Mostly, direct compression excipients are dried; therefore porous structure was produced as a Result. This property is characterized by a relatively low bulk density.
The Degree of Polymerization (DoP) expresses the number of Glucose units (C6H10O5) in the Cellulose chain. It decreases exponentially as a function of hydrolysis conditions
Zelsion Indstries having professional promoter Background with, Ultramodern Plant Situated in pollution Free Industrial estate at Ankleshwar, Gujarat, India. Established in 2021, Zelsion has been working towards Strengthening our manufacturing base and product Portfolio. The company focuses on continuously reviewing Opportunities in the pharmaceutical industry as well as Other growing segments to offer new and innovative Products. ZELSION is a Technology driven company Setting up high benchmarks for excellence in Product Quality and adherence to stringent delivery Schedule.
Maintaining consistency and strict input acceptance criteria in quality of all raw materials.
Maintaining operation parameters within the defined three sigma range.
Continuous and rigorous training sessions to all employees which include on the job training, procedural training, and IH training.
Stringent testing of frequencies and in-process limits.
The MCC can be synthesized by steam explosion and acid hydrolysis process. The acid Hydrolysis process is more preferable due to shorter duration than others. It also offered the Possibility to be applied as a continuous process rather than a batch-type process. Limited Quantity of consumed acid is also the advantage of the process, while, despite the lower unit Cost from less chemicals used, this process offered more fine particles of the MCC as the final Product. Fibrous plant pulp is hydrolyzed by mineral acid under heat and pressure. In the Presence of water and acid, hydrolysis process breaks cellulose polymers into smaller chain Polymers or micro crystals.
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